![]() ![]() To reduce the development of drug-resistant bacteria and maintain the effectiveness of nitrofurantoin macrocrystals capsules and other antibacterial drugs, nitrofurantoin macrocrystals capsules should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. Nitrofurantoin is not indicated for the treatment of pyelonephritis or perinephric abscesses. MIC for most susceptible organisms is 32 µg/ml which is easily attained in urine but not in the serum and tissues.īecause of the low tissue levels, nitrofurantoin should not be used to treat UTI with associated renal cortical or perinephric abscess.Nitrofurantoin macrocrystals capsules is specifically indicated for the treatment of urinary tract infections when due to susceptible strains of Escherichia coli, enterococci, Staphylococcus aureus, and certain susceptible strains of Klebsiella and Enterobacter species. The peak serum concentration after a single 100 mg oral nitrofurantoin dose is <2 µg/ml and the urine concentrations are known to be 50-200 µg/ml. Nitrofurantoin should not be administered when the possibility of bacteremia exists, as the drug does not achieve therapeutic serum levels when administered orally. Intravenous nitrofurantoin is unsuitable for the treatment of systemic infections of any kind because of poor serum levels.įollowing absorption, concentrations of nitrofurantoin in blood and body tissues are low because of rapid elimination and therefore, antibacterial concentrations are not achieved. but this is rarely used and and the parenteral preparation is not generally available. Without a doubt, literatures claim that the sole use of the drug is in the treatment of Urinary Tract Infection (UTI), as after oral or intravenous (i.v.) administration, therapeutically active concentrations are attained only in urine. But will it really be helpful in the wound infection? Recently, a wound swab culture and sensitivity reported an E.coli sensitive to Nitrofurantoin. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. Archives
December 2022
Categories |